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Article

Plot twist: TET2 clones save the brain.

Cell stem cell - 7 Aug 2025

Telpoukhovskaia Maria A, Trowbridge Jennifer J

Abstract excerpt

While clonal hematopoiesis (CH) is associated with protection from Alzheimer's disease (AD), a limited understanding of the mechanisms by which this occurs has been a barrier to therapeutic intervention. In a new study, Matatall et al.1 discover protective mechanisms by which TET2-mutant, but not DNMT3A-mutant, CH impacts dementia pathology and cognition.

Read the complete abstract on PubMed

Topics

Dioxygenases
Brain
Proto-Oncogene Proteins
Humans
DNA-Binding Proteins
Animals
Alzheimer Disease
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Methyltransferase 3A

Source

Identifiers

PMID: 40780187
DOI: 10.1016/j.stem.2025.07.001

Genes

TET2
DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Plot twist: TET2 clones save the brain.PMID 40780187Read ↗

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