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Article

A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization.

Genes, brain, and behavior - 1 Feb 2017

Stottmann Rolf W, Driver Ashley, Gutierrez Arnold, Skelton Matthew R, Muntifering Michael, Stepien Christopher, Knudson Luke, Kofron Matthew, Vorhees Charles V, Williams Michael T

Abstract excerpt

Development of the mammalian forebrain requires a significant contribution from tubulin proteins to physically facilitate both the large number of mitoses in the neurogenic brain (in the form of mitotic spindles) as well as support cellular scaffolds to guide radial migration (radial glial neuroblasts). Recent studies have identified a number of mutations in human tubulin genes affecting the forebrain, including...

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Identifiers

PMID: 27594048
DOI: 10.1111/gbb.12327
PMCID: PMC5290086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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