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Article

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.

PLoS biology - 1 Jun 2016

Ali Yousuf O, Allen Hunter M, Yu Lei, Li-Kroeger David, Bakhshizadehmahmoudi Dena, Hatcher Asante, McCabe Cristin, Xu Jishu, Bjorklund Nicole, Taglialatela Giulio, Bennett David A, De Jager Philip L, Shulman Joshua M, Bellen Hugo J, Lu Hui-Chen

Abstract excerpt

Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurodegeneration. Here, we show that brain nmnat2 mRNA levels correlate positively with global cognitive function and negatively with AD pathology. In AD brains, NMNAT2 mRNA and protein levels are reduced. NMNAT2 shifts its solubility and colocalizes with aggregated Tau in AD brains, similar to...

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Identifiers

PMID: 27254664
DOI: 10.1371/journal.pbio.1002472
PMCID: PMC4890852

Genes

NMNAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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