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An extracellular vesicle based hypothesis for the genesis of the polycystic kidney diseases

26 Jul 2024

Abstract excerpt

Autosomal dominant polycystic kidney (ADPKD) disease is the commonest genetic cause of kidney failure (affecting 1:800 individuals) and is due to heterozygous germline mutations in either of two genes, PKD1 and PKD2. Homozygous germline mutations in PKHD1 are responsible for autosomal recessive polycystic kidney (ARPKD) disease a rare (1:20,000) but severe neonatal disease. The products of these three genes, PKD1...

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PMID: 39886526
DOI: 10.1016/j.vesic.2024.100048

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