Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.

doi:10.1126/sciadv.aao0665

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Article

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.

Science advances - 1 Feb 2018

Parks Matthew M, Kurylo Chad M, Dass Randall A, Bojmar Linda, Lyden David, Vincent C Theresa, Blanchard Scott C

Abstract excerpt

The ribosome, the integration point for protein synthesis in the cell, is conventionally considered a homogeneous molecular assembly that only passively contributes to gene expression. Yet, epigenetic features of the ribosomal DNA (rDNA) operon and changes in the ribosome's molecular composition have been associated with disease phenotypes, suggesting that the ribosome itself may possess inherent regulatory...

Topics

Alleles
Animals
Base Sequence
Chromosomes, Human
Conserved Sequence
DNA, Ribosomal
Evolution, Molecular
Gene Dosage
Gene Expression Profiling
Gene Expression Regulation
Genome, Human
HEK293 Cells
Humans
Mice

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Operon

Organ Specificity

Protein Biosynthesis

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Identifiers

PMID: 29503865
DOI: 10.1126/sciadv.aao0665
PMCID: PMC5829973

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