Article
An intergenic non-coding rRNA correlated with expression of the rRNA and frequency of an rRNA single nucleotide polymorphism in lung cancer cells.
PloS one - 19 Oct 2009
Shiao Yih-Horng, Lupascu Sorin T, Gu Yuhan D, Kasprzak Wojciech, Hwang Christopher J, Fields Janet R, Leighty Robert M, Quiñones Octavio, Shapiro Bruce A, Alvord W Gregory, Anderson Lucy M
Abstract excerpt
BACKGROUND: Ribosomal RNA (rRNA) is a central regulator of cell growth and may control cancer development. A cis noncoding rRNA (nc-rRNA) upstream from the 45S rRNA transcription start site has recently been implicated in control of rRNA transcription in mouse fibroblasts. We investigated whether a similar nc-rRNA might be expressed in human cancer epithelial cells, and related to any genomic characteristics....
Topics
- Animals
- Cell Line
- Cell Line, Tumor
- Cloning, Molecular
- Fibroblasts
- Genomics
- Humans
- Lung
- Lung Neoplasms
- Mice
- Models, Genetic