Article
Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6-7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related Kinase A.
International journal of molecular sciences - 3 Nov 2020
Guadagni Stefano, Farina Antonietta Rosella, Cappabianca Lucia Annamaria, Sebastiano Michela, Maccarone Rita, Zelli Veronica, Clementi Marco, Chiominto Alessandro, Bruera Gemma, Ricevuto Enrico, Fiorentini Giammaria, Sarti Donatella, Mackay Andrew Reay
Abstract excerpt
Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which are caused by the genomic integration of Merkel cell polyomavirus (MCPyV). MCPyV-positive MCCs carry poor prognosis in approximately 70% of cases, highlighting the need for greater understanding of the oncogenic mechanisms involved in pathogenesis, progression and post-therapeutic relapse, and...
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