Article
Polyomavirus-Positive Merkel Cell Carcinoma Derived from a Trichoblastoma Suggests an Epithelial Origin of this Merkel Cell Carcinoma.
The Journal of investigative dermatology - 1 May 2020
Kervarrec Thibault, Aljundi Mohanad, Appenzeller Silke, Samimi Mahtab, Maubec Eve, Cribier Bernard, Deschamps Lydia, Sarma Bhavishya, Sarosi Eva-Maria, Berthon Patricia, Levy Annie, Bousquet Guilhem, Tallet Anne, Touzé Antoine, Guyétant Serge, Schrama David, Houben Roland
Abstract excerpt
Merkel cell carcinoma (MCC), an aggressive neuroendocrine carcinoma of the skin, is to date the only human cancer known to be frequently caused by a polyomavirus. However, it is a matter of debate which cells are targeted by the Merkel cell polyomavirus (MCPyV) to give rise to the phenotypically multifaceted MCC cells. To assess the lineage of origin of MCPyV-positive MCC, genetic analysis of a very rare tumor...
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