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The Complement C3a and C3a Receptor Pathway in Kidney Diseases

18 Aug 2020

Abstract excerpt

The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role. C3a/C3aR has dual roles and may exert anti-inflammatory or pro-inflammatory effects depending on different cell types and diseases. In the kidneys, C3aR is primarily expressed on the tubular epithelium and less in glomerular podocytes. C3aR expression is enhanced...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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PMID: 32973774
DOI: 10.3389/fimmu.2020.01875

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