Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2021

Zawia Amira, Arnold Nadine D, West Laura, Pickworth Josephine A, Turton Helena, Iremonger James, Braithwaite Adam T, Cañedo Jaime, Johnston Simon A, Thompson A A Roger, Miller Gaynor, Lawrie Allan

Abstract excerpt

OBJECTIVE: To determine whether global reduction of CD68 (cluster of differentiation) macrophages impacts the development of experimental pulmonary arterial hypertension (PAH) and whether this reduction affects the balance of pro- and anti-inflammatory macrophages within the lung. Additionally, to determine whether there is evidence of an altered macrophage polarization in patients with PAH. Approach and Results:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, Myelomonocytic
Share to Diphtheria Toxin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophage Activation

Share to Macrophages, Alveolar

Share to Paracrine Communication

Share to Pulmonary Arterial Hypertension

Share to Pulmonary Artery

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 33147993
DOI: 10.1161/ATVBAHA.120.314639
PMCID: PMC7752239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension.PMID 33147993Read ↗

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension.Semantic proximity Read ↗

Phenotype and function of macrophage polarization in monocrotaline-induced pulmonary arterial hypertension rat model.Semantic proximity Read ↗

Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.Semantic proximity Read ↗

Immunoregulatory macrophages modify local pulmonary immunity and ameliorate hypoxic-pulmonary hypertensionSemantic proximity Read ↗

BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor alpha is essential factor in enhanced macrophage immune function induced by angiotensin converting enzymeSemantic proximity Read ↗

Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension.Semantic proximity Read ↗

Alveolar macrophage populations are distorted in immunocompromised patients with pneumonitis.Semantic proximity Read ↗

Phenotypical and functional characterization of alveolar macrophage subpopulations in the lungs of NO2-exposed rats.Semantic proximity Read ↗

Altered macrophage phenotype transition impairs skeletal muscle regeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.