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Panel-based RNA fusion sequencing improves diagnostics of pediatric acute myeloid leukemia

12 Dec 2023

Abstract excerpt

New methods like panel-based RNA fusion sequencing (RNA-FS) promise improved diagnostics in various malignancies. We here analyzed the impact of RNA-FS on the initial diagnostics of 241 cases with pediatric acute myeloid leukemia (AML). We show that, compared to classical cytogenetics (CCG), RNA-FS reliably detected risk-relevant fusion genes in pediatric AML. In addition, RNA-FS strongly improved the detection...

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PMID: 38086945
DOI: 10.1038/s41375-023-02102-9

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