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Article

Demographic history and selection at HLA loci in Native Americans.

PloS one - 1 Jan 2020

Single Richard M, Meyer Diogo, Nunes Kelly, Francisco Rodrigo Santos, Hünemeier Tábita, Maiers Martin, Hurley Carolyn K, Bedoya Gabriel, Gallo Carla, Hurtado Ana Magdalena, Llop Elena, Petzl-Erler Maria Luiza, Poletti Giovanni, Rothhammer Francisco, Tsuneto Luiza, Klitz William, Ruiz-Linares Andrés

Abstract excerpt

The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this demographic history has shaped genetic variation at the strongly selected HLA loci. In order to disentangle the relative contributions of selection and demography process, we assembled a dataset...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33147239
DOI: 10.1371/journal.pone.0241282
PMCID: PMC7641399

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