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Article

Racial and Ethnic Differences in Multigene Hereditary Cancer Panel Test Results for Women With Breast Cancer.

Journal of the National Cancer Institute - 1 Oct 2021

Yadav Siddhartha, LaDuca Holly, Polley Eric C, Hu Chunling, Niguidula Nancy, Shimelis Hermela, Lilyquist Jenna, Na Jie, Lee Kun Y, Gutierrez Stephanie, Yussuf Amal, Hart Steven N, Davis Brigette Tippin, Chao Elizabeth C, Pesaran Tina, Goldgar David E, Dolinsky Jill S, Couch Fergus J

Abstract excerpt

To evaluate the racial and ethnic differences in prevalence of germline pathogenic variants (PVs) and the effect of race and ethnicity on breast cancer (BC) risk among carriers, results of multigene testing of 77 900 women with BC (non-Hispanic White [NHW] = 57 003; Ashkenazi-Jewish = 4798; Black = 6722; Hispanic = 5194; and Asian = 4183) were analyzed, and the frequency of PVs in each gene were compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33146377
DOI: 10.1093/jnci/djaa167
PMCID: PMC8633452

Genes

CHEK2
ATM
BARD1
BRCA1
BRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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