Article
BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer.
Cancer - 15 May 2009
Hall Michael J, Reid Julia E, Burbidge Lynn A, Pruss Dmitry, Deffenbaugh Amie M, Frye Cynthia, Wenstrup Richard J, Ward Brian E, Scholl Thomas A, Noll Walter W
Abstract excerpt
BACKGROUND: In women at increased risk for breast and ovarian cancer, the identification of a mutation in breast cancer gene 1 (BRCA1) and BRCA2 has important implications for screening and prevention counseling. Uncertainty regarding the role of BRCA1 and BRCA2 testing in high-risk women from diverse ancestral backgrounds exists because of variability in prevalence estimates of deleterious (disease-associated)...
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