Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted next-generation sequencing identified novel mutations in triple-negative myeloproliferative neoplasms.

Medical oncology (Northwood, London, England) - 1 May 2017

Chang Yu-Cheng, Lin Huan-Chau, Chiang Yi-Hao, Chen Caleb Gon-Shen, Huang Ling, Wang Wei-Ting, Cheng Chun-Chia, Lin Johnson, Chang Yi-Fang, Chang Ming-Chih, Hsieh Ruey-Kuen, Chen Shu-Jen, Lim Ken-Hong, Kuo Yuan-Yeh

Abstract excerpt

Mutations in JAK2, MPL and CALR genes have been identified in the majority of myeloproliferative neoplasm (MPN) patients, and patients negative for these three mutations are the so-called triple-negative (TN) MPN. In this study, we examined the mutational profiles of 16 triple-negative MPN patients including 7 essential thrombocythemia (ET), 1 primary myelofibrosis and 8 polycythemia vera (PV). Targeted...

Topics

Join the communities discussing this publication.

Aged, 80 and over
Calreticulin
DNA Mutational Analysis
DNA, Neoplasm
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloproliferative Disorders

Receptors, Thrombopoietin

Source

Identifiers

PMID: 28389907
DOI: 10.1007/s12032-017-0944-z

Genes

ATM
CALR
CCND2
IRS2
JAK2
MPL
SETD2
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted next-generation sequencing identified novel mutations in triple-negative myeloproliferative neoplasms.PMID 28389907Read ↗

Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms.Semantic proximity Read ↗

Novel modes of MPL activation in triple-negative myeloproliferative neoplasms.Semantic proximity Read ↗

Rapid Molecular Profiling of Myeloproliferative Neoplasms Using Targeted Exon Resequencing of 86 Genes Involved in JAK-STAT Signaling and Epigenetic Regulation.Semantic proximity Read ↗

Non-MPL-W515K/L mutations in myeloproliferative neoplasms: Insights from two case reports and a review of the literature.Semantic proximity Read ↗

Understanding Triple Negative Myeloproliferative Neoplasms and Identifying Molecular Drivers.Semantic proximity Read ↗

Mutations in myeloproliferative neoplasms - their significance and clinical use.Semantic proximity Read ↗

Genetic basis and molecular profiling in myeloproliferative neoplasms.Semantic proximity Read ↗

Understanding triple negative myeloproliferative neoplasms: pathogenesis, clinical features, and management.Semantic proximity Read ↗

Clinicopathological differences exist between CALR- and JAK2-mutated myeloproliferative neoplasms despite a similar molecular landscape: data from targeted next-generation sequencing in the diagnostic laboratory.Semantic proximity Read ↗

Mutational profiling in suspected triple-negative essential thrombocythaemia using targeted next-generation sequencing in a real-world cohort.Semantic proximity Read ↗

Molecular testing for JAK2, MPL, and CALR in myeloproliferative neoplasms.Semantic proximity Read ↗

Germline variants in DNA repair genes, including BRCA1/2, may cause familial myeloproliferative neoplasmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.