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The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

5 Feb 2020

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two diseases that form a broad neurodegenerative continuum. Considerable effort has been made to unravel the genetics of these disorders, and, based on this work, it is now clear that ALS and FTD have a significant genetic overlap. TARDBP, SQSTM1, VCP, FUS, TBK1, CHCHD10, and most importantly C9orf72, are the critical genetic players in...

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PMID: 32116499
DOI: 10.3389/fnins.2020.00042

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