Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)

20 Mar 2025

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two extremes of a neurodegenerative disease spectrum characterised by overlapping genetic, clinical, and neuropathological features. This review covers the intricate relationship between both ALS and FTD and defects in the autophagy and endolysosomal pathway as recent evidence has pointed towards alterations in these pathways as being...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Autophagy in Disease and Therapy
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40395983
DOI: 10.1080/27694127.2025.2474796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)PMID 40395983Read ↗

Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting.Semantic proximity Read ↗

The endolysosomal pathway and ALS/FTD.Semantic proximity Read ↗

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Semantic proximity Read ↗

The Interplay Between Autophagy and RNA Homeostasis: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal DementiaSemantic proximity Read ↗

Implications of Selective Autophagy Dysfunction for ALS PathologySemantic proximity Read ↗

Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy MenuSemantic proximity Read ↗

Role of autophagy and proteostasis in neurodegenerative diseases: Exploring the therapeutic interventionsSemantic proximity Read ↗

Autophagy in Rare (NonLysosomal) Neurodegenerative DiseasesSemantic proximity Read ↗

Role of autophagy in the pathogenesis of amyotrophic lateral sclerosisSemantic proximity Read ↗

Relevance of Autophagy and Mitophagy Dynamics and Markers in Neurodegenerative DiseasesSemantic proximity Read ↗

Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's diseaseSemantic proximity Read ↗

Neuronal autophagy and neurodegenerative diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.