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HorkaD, a chromosome instability-causing mutation in Drosophila, is a dominant-negative allele of Lodestar.

Genetics - 1 Feb 2009

Szalontai Tamas, Gaspar Imre, Belecz Istvan, Kerekes Iren, Erdelyi Miklos, Boros Imre, Szabad Janos

Abstract excerpt

Correct segregation of chromosomes is particularly challenging during the rapid nuclear divisions of early embryogenesis. This process is disrupted by Horka(D), a dominant-negative mutation in Drosophila melanogaster that causes female sterility due to chromosome tangling and nondisjunction during oogenesis and early embryogenesis. Horka(D) also renders chromosomes unstable during spermatogenesis, which leads to...

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Identifiers

PMID: 19047413
DOI: 10.1534/genetics.108.097345
PMCID: PMC2644933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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