Article
Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations.
Genes - 29 Oct 2020
Cismaru Anca Liliana, Rudin Deborah, Ibañez Luisa, Liakoni Evangelia, Bonadies Nicolas, Kreutz Reinhold, Carvajal Alfonso, Lucena Maria Isabel, Martin Javier, Sancho Ponce Esther, Molokhia Mariam, Eriksson Niclas, EuDAC Collaborators, Krähenbühl Stephan, Largiadèr Carlo R, Haschke Manuel, Hallberg Pär, Wadelius Mia, Amstutz Ursula
Abstract excerpt
Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic widely used in countries such as Switzerland and Germany. Notably, an underlying mechanism has not yet been fully elucidated and no predictive factors are known to identify at-risk patients. With the aim to identify genetic susceptibility variants to metamizole-induced agranulocytosis (MIA) and neutropenia (MIN),...
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