Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integration analysis of GWAS and expression quantitative trait loci to identify candidate genes and pathways for clozapine-related neutropaenia.

British journal of clinical pharmacology - 1 Feb 2022

Li Jiqing, Tang Fang, Si Shucheng, Wang Bojie, Xue Fuzhong

Abstract excerpt

AIMS: Little is known about the genetic basis of clozapine-related neutropaenia. This study aims to explore candidate genes and pathways involved in clozapine-related neutropaenia. METHODS: This study conducted a two-stage integrative analysis of the summary statistics from the genome-wide association study (GWAS, n = 552) of the lowest absolute neutrophil count (ANC) during clozapine treatment and the summary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Clozapine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Neutropenia

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 34409637
DOI: 10.1111/bcp.15043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integration analysis of GWAS and expression quantitative trait loci to identify candidate genes and pathways for clozapine-related neutropaenia.PMID 34409637Read ↗

Genetic risk of clozapine-induced leukopenia and neutropenia: a genome-wide association studySemantic proximity Read ↗

Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropeniaSemantic proximity Read ↗

Mediation and Longitudinal Analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil countSemantic proximity Read ↗

Potential Pleiotropic Genes and Shared Biological Pathways in Epilepsy and Depression Based on GWAS Summary Statistics.Semantic proximity Read ↗

Candidate disease genes identification in patients with congenital neutropenia and a new PID conditionSemantic proximity Read ↗

Purine Metabolism-Related Pathogenic Genes in Trigeminal Neuralgia: A Multiomics Mendelian Randomization Study.Semantic proximity Read ↗

Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population.Semantic proximity Read ↗

Carbamazepine-induced thrombocytopenic purpura in a child: Insights from a genomic analysis.Semantic proximity Read ↗

Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population.Semantic proximity Read ↗

Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population.Semantic proximity Read ↗

Risk assessment in fever and neutropenia in children with cancer: What did we learn?Semantic proximity Read ↗

Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.