TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma.

doi:10.1007/s00401-021-02300-8

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Article

TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma.

Acta neuropathologica - 1 Jun 2021

Thomas Christian, Thierfelder Felix, Träger Malte, Soschinski Patrick, Müther Michael, Edelmann Dominic, Förster Alexandra, Geiler Carola, Kim Hee-Yeong, Filipski Katharina, Harter Patrick N, Schittenhelm Jens, Eckert Franziska, Ntoulias Georgios, May Sven-Axel, Stummer Walter, Onken Julia, Vajkoczy Peter, Schüller Ulrich, Heppner Frank L, Capper David, Koch Arend, Kaul David, Paulus Werner, Hasselblatt Martin, Schweizer Leonille

Abstract excerpt

Subependymomas are benign tumors characteristically encountered in the posterior fossa of adults that show distinct epigenetic profiles assigned to the molecular group "subependymoma, posterior fossa" (PFSE) of the recently established DNA methylation-based classification of central nervous system tumors. In contrast, most posterior fossa ependymomas exhibit a more aggressive biological behavior and are allocated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33755803
DOI: 10.1007/s00401-021-02300-8
PMCID: PMC8113189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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