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Article

Reduced monoaminergic nuclei MRI signal detectable in pre-symptomatic older adults with future memory decline.

Scientific reports - 30 Oct 2020

Venneri Annalena, De Marco Matteo

Abstract excerpt

Evidence from murine models and human post-mortem studies indicates that monoaminergic nuclei undergo degeneration at the pre-symptomatic stage of Alzheimer's disease (AD). Analysing 129 datasets from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and relying on the Clinical Dementia Rating as group-defining instrument, we hypothesised that the MRI signal of monoaminergic nuclei would be a statistically...

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Identifiers

PMID: 33127923
DOI: 10.1038/s41598-020-71368-1
PMCID: PMC7603335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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