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Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status

3 Jun 2024

Abstract excerpt

The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest sites of tauopathy in Alzheimer's disease (AD). They project broadly throughout the brain's white matter. We investigated the relationship between IdC microstructure and whole-brain white matter microstructure to better understand early neuropathological changes in AD. Using multiparametric quantitative magnetic resonance...

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PMID: 38830849
DOI: 10.1038/s41467-024-48490-z

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