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Article

Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts.

JAMA psychiatry - 1 Aug 2024

Grimes Poppy Z, Adams Mark J, Thng Gladi, Edmonson-Stait Amelia J, Lu Yi, McIntosh Andrew, Cullen Breda, Larsson Henrik, Whalley Heather C, Kwong Alex S F

Abstract excerpt

Importance: Adolescent depression is characterized by diverse symptom trajectories over time and has a strong genetic influence. Research has determined genetic overlap between depression and other psychiatric conditions; investigating the shared genetic architecture of heterogeneous depression trajectories is crucial for understanding disease etiology, prediction, and early intervention. Objective: To...

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Identifiers

PMID: 38748406
DOI: 10.1001/jamapsychiatry.2024.0983
PMCID: PMC11097103

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