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Article

Genetic polymorphisms of miRNA machinery genes in bicuspid aortic valve and associated aortopathy.

Personalized medicine - 1 Jan 2021

Vecoli Cecilia, Borghini Andrea, Turchi Stefano, Mercuri Antonella, Andreassi Maria Grazia

Abstract excerpt

Aim: SNPs in miRNA machinery genes may affect miRNA function by impacting their biogenesis. Here, we investigated the association between three SNPs in miRNA machinery genes (DICER rs1057035, DROSHA rs10719 and XPO5 rs11077) and bicuspid aortic valve (BAV). Materials & methods: Three polymorphisms were analyzed in 177 BAV patients and 414 healthy subjects by using a TaqMan®SNP assay. Results: The frequencies of...

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PMID: 33124523
DOI: 10.2217/pme-2020-0082

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