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Article

Individual and joint effects of genetic polymorphisms in microRNA-machinery genes on congenital heart disease susceptibility.

Cardiology in the young - 1 Jun 2021

Borghini Andrea, Vecoli Cecilia, Mercuri Antonella, Turchi Stefano, Andreassi Maria Grazia

Abstract excerpt

Single-nucleotide polymorphisms in miRNA-machinery genes may alter the biogenesis of miRNAs affecting disease susceptibility. In this case-control study, we aimed to evaluate the impact of three single-nucleotide polymorphisms (DICER rs1057035, DROSHA rs10719, and XPO5 rs11077) and their combined effect in a genetic risk score model on congenital heart disease (CHD) risk. A total of 639 participants was...

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PMID: 33423710
DOI: 10.1017/S1047951120004874

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