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Article

MiR-145 expression and rare NOTCH1 variants in bicuspid aortic valve-associated aortopathy.

PloS one - 1 Jan 2018

Girdauskas Evaldas, Petersen Johannes, Neumann Niklas, Ungelenk Martin, Kurth Ingo, Reichenspurner Hermann, Zeller Tanja

Abstract excerpt

MicroRNAs (miRNAs) may serve as elegant tool to improve risk stratification in bicuspid aortic valve (BAV)-associated aortopathy. However, the exact pathogenetic pathway by which miRNAs impact aortopathy progression is unknown. Herewith, we aimed to analyze the association between circulating miRNAs and rare variants of aortopathy-related genes. 63 BAV patients (mean age 47.3±11.3 years, 92% male) with a root...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30059548
DOI: 10.1371/journal.pone.0200205
PMCID: PMC6066209

Genes

NOTCH1

Provenance

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