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Article

Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum.

Frontiers in immunology - 1 Jan 2020

Lodde Valeria, Floris Matteo, Beerman Isabel, Munk Rachel, Guha Rajan, Steri Maristella, Orrù Valeria, Abdelmohsen Kotb, Crompton Peter D, Gorospe Myriam, Idda Maria Laura, Cucca Francesco

Abstract excerpt

We have previously shown that a variant of the TNFSF13B gene that we called BAFF-var increases the production of the cytokine BAFF, upregulating humoral immunity and increasing the risk for certain autoimmune diseases. In addition, genetic population signatures revealed that BAFF-var was evolutionarily advantageous, most likely by increasing resistance to malaria infection, which is a prime candidate for...

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Identifiers

PMID: 33123155
DOI: 10.3389/fimmu.2020.575103
PMCID: PMC7573158

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