Article
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax.
PloS one - 1 Jan 2016
Cassiano Gustavo C, Furini Adriana A C, Capobianco Marcela P, Storti-Melo Luciane M, Cunha Maristela G, Kano Flora S, Carvalho Luzia H, Soares Irene S, Santos Sidney E, Póvoa Marinete M, Machado Ricardo L D
Abstract excerpt
The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally...
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