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Article

Sequential, Ordered Acquisition of Antibodies to <i>Plasmodium falciparum</i> Erythrocyte Membrane Protein 1 Domains

12 Aug 2009

Abstract excerpt

The binding of erythrocytes infected with mature blood stage parasites to the vascular bed is key to the pathogenesis of malignant malaria. The binding is mediated by members of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family. PfEMP1s can be divided into groups, and it has previously been suggested that parasites expressing group A or B/A PfEMP1s are most pathogenic. To test the hypothesis...

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PMID: 19675168
DOI: 10.4049/jimmunol.0901331

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