Article
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Aug 2021
Sonon Paulin, Tokplonou Léonidas, Sadissou Ibrahim, M'po Kuumaaté K G, Glitho Sonya S C, Agniwo Privat, Ibikounlé Moudachirou, Souza Andréia S, Massaro Juliana Doblas, Gonzalez Daniel, Tchégninougbo Théophile, Ayitchédji Aurèle, Massougbodji Achille, Moreau Philippe, Garcia André, Milet Jacqueline, Sabbagh Audrey, Mendes-Junior Celso T, Moutairou Kabirou A, Castelli Erick C, Courtin David, Donadi Eduardo A
Abstract excerpt
BACKGROUND: Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/-G genes in malaria. We evaluated the entire HLA-E/-F/-G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. METHODS: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. HLA-E/-F/-G genes were genotyped using massively...
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