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Article

MicroRNA-301a inhibition enhances the immunomodulatory functions of adipose-derived mesenchymal stem cells by induction of macrophage M2 polarization.

International journal of immunopathology and pharmacology - 1 Jan 2000

Hsu Li-Wen, Huang Kuang-Tzu, Nakano Toshiaki, Chiu King-Wah, Chen Kuang-Den, Goto Shigeru, Chen Chao-Long

Abstract excerpt

MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a significant role in biological processes in various cell types, including mesenchymal stem cells (MSCs). However, how miRNAs regulate the immunomodulatory functions of adipose-derived MSCs (AD-MSCs) remains unknown. Here, we showed that modulation of miR-301a in AD-MSCs altered macrophage polarization. Bone marrow (BM)-derived macrophages were...

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Identifiers

PMID: 33121303
DOI: 10.1177/2058738420966092
PMCID: PMC7607751

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