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Article

SF3B1-mutated chronic lymphocytic leukemia shows evidence of NOTCH1 pathway activation including CD20 downregulation

Haematologica - 1 Dec 2021

Pozzo Federico, Bittolo Tamara, Tissino Erika, Vit Filippo, Vendramini Elena, Laurenti Luca, D'Arena Giovanni, Olivieri Jacopo, Pozzato Gabriele, Zaja Francesco, Chiarenza Annalisa, Di Raimondo Francesco, Zucchetto Antonella, Bomben Riccardo, Rossi Francesca Maria, Del Poeta Giovanni, Dal Bo Michele, Gattei Valter

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is characterized by a low CD20 expression, in part explained by an epigenetic-driven downregulation triggered by mutations of the NOTCH1 gene. In the present study, by taking advantage of a wide and well-characterized CLL cohort (n=537), we demonstrate that CD20 expression is downregulated in SF3B1-mutated CLL in an extent similar to NOTCH1-mutated CLL. In fact, SF3B1-mutated...

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Share to Antigens, CD20
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 33121237
DOI: 10.3324/haematol.2020.261891
PMCID: PMC8634191

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