Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV.

doi:10.1111/bjh.14312

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Article

Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV.

British journal of haematology - 1 Dec 2016

Poppova Lucie, Janovska Pavlina, Plevova Karla, Radova Lenka, Plesingerova Hana, Borsky Marek, Kotaskova Jana, Kantorova Barbara, Hlozkova Michaela, Figulova Jana, Brychtova Yvona, Machalova Michaela, Urik Milan, Doubek Michael, Kozubik Alois, Pospisilova Sarka, Pavlova Sarka, Bryja Vitezslav

Abstract excerpt

The canonical Wnt pathway, dependent on β-catenin-controlled transcription, is the most explored Wnt pathway, known to drive the malignant transformation of multiple cell types. Several reports have suggested that this pathway also participates in chronic lymphocytic leukaemia (CLL) pathogenesis. To get a better insight into the role of the Wnt/β-catenin pathway in CLL we analysed in detail the expression of the...

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Identifiers

PMID: 27651098
DOI: 10.1111/bjh.14312

Genes

WNT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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