Article
Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells.
Molecular therapy : the journal of the American Society of Gene Therapy - 4 Apr 2018
Spear Timothy T, Wang Yuan, Smith Thomas W, Simms Patricia E, Garrett-Mayer Elizabeth, Hellman Lance M, Baker Brian M, Nishimura Michael I
Abstract excerpt
The use of T cell receptor (TCR) gene-modified T cells in adoptive cell transfer has had promising clinical success, but often, simple preclinical evaluation does not necessarily accurately predict treatment efficacy or safety. Preclinical studies generally evaluate one or a limited number of type 1 cytokines to assess antigen recognition. However, recent studies have implicated other "typed" T cells in effective...
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