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Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

28 Oct 2020

Abstract excerpt

Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after allo-HCT exhibited reduced glycolysis and interferon-γ production. Functional studies in multiple mouse models of leukemia showed that leukemia-derived lactic acid (LA) interfered with T cell glycolysis and proliferation....

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PMID: 33115954
DOI: 10.1126/scitranslmed.abb8969

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