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Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core

11 Mar 2010

Abstract excerpt

After membrane fusion with a target cell, the core of human immunodeficiency virus type 1 (HIV-1) enters into the cytoplasm, where uncoating occurs. The cone-shaped core is composed of the viral capsid protein (CA), which disassembles during uncoating. The underlying factors and mechanisms governing uncoating are poorly understood. Several CA mutations can cause changes in core stability and a block at reverse...

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PMID: 20219923
DOI: 10.1128/jvi.02382-09

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