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Article

Stimulation of GMP formation in hGBP1 is mediated by W79 and its effect on the antiviral activity.

The FEBS journal - 1 May 2021

Raninga Nikunj, Nayeem Shahid M, Gupta Sowmiya, Mullick Ranajoy, Pandita Esha, Das Saumitra, Deep Shashank, Sau Apurba Kumar

Abstract excerpt

Interferon-inducible large GTPases are critical for innate immunity. The distinctive feature of a large GTPase, human guanylate binding protein-1 (hGBP1), is the sequential hydrolysis of GTP into GMP via GDP. Despite several structural and biochemical studies, the underlying mechanism of assembly-stimulated GMP formation by hGBP1 and its role in immunity are not fully clarified. Using a series of biochemical,...

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PMID: 33113220
DOI: 10.1111/febs.15611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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