Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis.

Journal of the American Chemical Society - 11 Mar 2015

Hover Bradley M, Yokoyama Kenichi

Abstract excerpt

The molybdenum cofactor (Moco) is an essential redox cofactor found in all kingdoms of life. Genetic mutations in the human Moco biosynthetic enzymes lead to a fatal metabolic disorder, Moco deficiency (MoCD). Greater than 50% of all human MoCD patients have mutations in MOCS1A, a radical S-adenosyl-l-methionine (SAM) enzyme involved in the conversion of guanosine 5'-triphosphate (GTP) into cyclic pyranopterin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon-Carbon Lyases
Share to Coenzymes
Share to Guanosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen

Share to Hydrolases

Share to Metalloproteins

Share to Molybdenum Cofactors

Share to Pteridines

Source

Open in PubMed Open full text

Identifiers

PMID: 25697423
DOI: 10.1021/ja512997j
PMCID: PMC4831585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis.PMID 25697423Read ↗

Accumulation of an unprecedented 5′-deoxyadenos-4′-yl radical unmasks the kinetics of the radical-mediated C-C bond formation step in MoaA catalysisSemantic proximity Read ↗

Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.Semantic proximity Read ↗

The functional principle of eukaryotic molybdenum insertases.Semantic proximity Read ↗

Identification and Computational Analysis of 3D-Structure Of MOCS1Semantic proximity Read ↗

Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.Semantic proximity Read ↗

Biogenesis of molybdenum cofactors.Semantic proximity Read ↗

Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion.Semantic proximity Read ↗

Radical S-Adenosylmethionine Enzymes in Human Health and Disease.Semantic proximity Read ↗

Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase.Semantic proximity Read ↗

Methionine gamma‐lyase: The unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancersSemantic proximity Read ↗

Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA.Semantic proximity Read ↗

A mild case of molybdenum cofactor deficiency defines an alternative route of MOCS1 protein maturation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.