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Article

Rationally-Stabilized Inhibited State of IMPDH Proposes a Novel Targeting Approach Involving Its Cross-Domain and Assembly Suppression.

Molecular biotechnology - 1 Apr 2026

Sattari Samira, Yazdanparast Razieh, Barzegari Ebrahim

Abstract excerpt

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step of GTP biosynthesis. The multilevel regulation of the enzyme complicates its inhibition to treat diseases such as retinitis pigmentosa (RP) where modulation of the isozyme IMPDH1 is disrupted by mutations in a GTP-binding site on its regulatory CBS domain. Here, we hypothesize that upsetting the ATP-binding site 1 on the CBS domain,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40643847
DOI: 10.1007/s12033-025-01474-w

Genes

CBS
IMPDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Rationally-Stabilized Inhibited State of IMPDH Proposes a Novel Targeting Approach Involving Its Cross-Domain and Assembly Suppression.PMID 40643847Read ↗

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