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Article

Epistasis Between Two Gene Variants of Leptin and Vascular Endothelial Growth Factor Genes in the Development of Primary Knee Osteoarthritis.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion - 15 Mar 2022

Sosa-Arellano Matvey, González-Huerta Norma C, Morales-Hernández Eugenio, Duarte-Salazar Carolina, Miranda-Duarte Antonio

Abstract excerpt

BACKGROUND: The association of leptin (LEP) and vascular endothelial growth factor A (VEGFA) genes with the susceptibility to knee osteoarthritis (OA) has been analyzed; however, the epistasis between them has not been investigated. OBJECTIVE: The objective of the study was to analyze the association of LEP and VEGFA variants and their interaction with primary knee OA in a Mexican Mestizo population. METHODS: A...

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Identifiers

PMID: 34983993
DOI: 10.24875/RIC.21000493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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