Article
Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations.
The Journal of clinical endocrinology and metabolism - 25 Mar 2021
Casar-Borota Olivera, Boldt Henning Bünsow, Engström Britt Edén, Andersen Marianne Skovsager, Baussart Bertrand, Bengtsson Daniel, Berinder Katarina, Ekman Bertil, Feldt-Rasmussen Ulla, Höybye Charlotte, Jørgensen Jens Otto L, Kolnes Anders Jensen, Korbonits Márta, Rasmussen Åse Krogh, Lindsay John R, Loughrey Paul Benjamin, Maiter Dominique, Manojlovic-Gacic Emilija, Pahnke Jens, Poliani Pietro Luigi, Popovic Vera, Ragnarsson Oskar, Schalin-Jäntti Camilla, Scheie David, Tóth Miklós, Villa Chiara, Wirenfeldt Martin, Kunicki Jacek, Burman Pia
Abstract excerpt
CONTEXT: Aggressive pituitary tumors (APTs) are characterized by unusually rapid growth and lack of response to standard treatment. About 1% to 2% develop metastases being classified as pituitary carcinomas (PCs). For unknown reasons, the corticotroph tumors are overrepresented among APTs and PCs. Mutations in the alpha thalassemia/mental retardation syndrome X-linked (ATRX) gene, regulating chromatin remodeling...
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