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Telomerase Activation and ATRX Mutations Are Independent Risk Factors for Metastatic Pheochromocytoma and Paraganglioma

9 Oct 2018

Abstract excerpt

Abstract Purpose: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors. Whereas most PPGLs are benign, up to 20% may become metastatic with SDHB- and FH-mutated tumors showing the higher risk. We aimed at determining the contribution of immortalization mechanisms to metastatic progression. Experimental Design: Immortalization mechanisms were investigated in 200 tumors. To identify...

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PMID: 30301828
DOI: 10.1158/1078-0432.ccr-18-0139

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