Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas.

Nature communications - 21 Jan 2015

Fishbein Lauren, Khare Sanika, Wubbenhorst Bradley, DeSloover Daniel, D'Andrea Kurt, Merrill Shana, Cho Nam Woo, Greenberg Roger A, Else Tobias, Montone Kathleen, LiVolsi Virginia, Fraker Douglas, Daber Robert, Cohen Debbie L, Nathanson Katherine L

Abstract excerpt

Pheochromocytomas and paragangliomas (PCC/PGL) are the solid tumour type most commonly associated with an inherited susceptibility syndrome. However, very little is known about the somatic genetic changes leading to tumorigenesis or malignant transformation. Here we perform whole-exome sequencing on a discovery set of 21 PCC/PGL and identify somatic ATRX mutations in two SDHB-associated tumours. Targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Gland Neoplasms
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Paraganglioma

Share to Pheochromocytoma

Share to Succinate Dehydrogenase

Share to Telomere Homeostasis

Share to X-linked Nuclear Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 25608029
DOI: 10.1038/ncomms7140
PMCID: PMC4302757

Genes

ATRX
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas.PMID 25608029Read ↗

ATRX driver mutation in a composite malignant pheochromocytoma.Semantic proximity Read ↗

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profilesSemantic proximity Read ↗

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profilesSemantic proximity Read ↗

Genetics of pheochromocytoma and paraganglioma.Semantic proximity Read ↗

Case Series: ATRX Variants in Four Patients with Metastatic Pheochromocytoma.Semantic proximity Read ↗

Clinical exome next‑generation sequencing panel for hereditary pheochromocytoma and paraganglioma diagnosisSemantic proximity Read ↗

The genetic landscape of high-risk neuroblastoma.Semantic proximity Read ↗

Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing.Semantic proximity Read ↗

Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas.Semantic proximity Read ↗

Optimizing Genetic Workup in Pheochromocytoma and Paraganglioma by Integrating Diagnostic and Research ApproachesSemantic proximity Read ↗

Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma.Semantic proximity Read ↗

The genomic landscape of phaeochromocytoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.