Article
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age.
Nature cell biology - 1 Nov 2020
García-Prat Laura, Perdiguero Eusebio, Alonso-Martín Sonia, Dell'Orso Stefania, Ravichandran Srikanth, Brooks Stephen R, Juan Aster H, Campanario Silvia, Jiang Kan, Hong Xiaotong, Ortet Laura, Ruiz-Bonilla Vanessa, Flández Marta, Moiseeva Victoria, Rebollo Elena, Jardí Mercè, Sun Hong-Wei, Musarò Antonio, Sandri Marco, Del Sol Antonio, Sartorelli Vittorio, Muñoz-Cánoves Pura
Abstract excerpt
Tissue regeneration declines with ageing but little is known about whether this arises from changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two quiescent stem-cell states distinguished by relative CD34 expression: CD34High, with stemness properties (genuine state), and CD34Low, committed to myogenic differentiation (primed state). The genuine-quiescent state is unexpectedly...
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