Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits.

The EMBO journal - 1 Aug 2022

Emmrich Stephan, Trapp Alexandre, Tolibzoda Zakusilo Frances, Straight Maggie E, Ying Albert K, Tyshkovskiy Alexander, Mariotti Marco, Gray Spencer, Zhang Zhihui, Drage Michael G, Takasugi Masaki, Klusmann Jan-Henning, Gladyshev Vadim N, Seluanov Andrei, Gorbunova Vera

Abstract excerpt

Naked mole rats (NMRs) are the longest-lived rodents yet their stem cell characteristics remain enigmatic. Here, we comprehensively mapped the NMR hematopoietic landscape and identified unique features likely contributing to longevity. Adult NMRs form red blood cells in spleen and marrow, which comprise a myeloid bias toward granulopoiesis together with decreased B-lymphopoiesis. Remarkably, youthful blood and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to CD34 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CDC42 gene

Share to Hematopoiesis

Share to Phenotype

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 35694726
DOI: 10.15252/embj.2021109694
PMCID: PMC9340489

Genes

CD34
CDC42
THY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits.PMID 35694726Read ↗

An abundant myeloid progenitor shapes neonatal hematopoiesis of naked mole-ratsSemantic proximity Read ↗

Stem cell heterogeneity: implications for aging and regenerative medicineSemantic proximity Read ↗

A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesisSemantic proximity Read ↗

Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell populationSemantic proximity Read ↗

Adult stem cell activity in naked mole rats for long-term tissue maintenanceSemantic proximity Read ↗

Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic HierarchySemantic proximity Read ↗

Atlas of Cynomolgus Macaque HematopoiesisSemantic proximity Read ↗

Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysisSemantic proximity Read ↗

Hematopoiesis during Ontogenesis, Adult Life, and AgingSemantic proximity Read ↗

The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging.Semantic proximity Read ↗

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.Semantic proximity Read ↗

Natural and age-related variation in circulating human hematopoietic stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.