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Article

Loss of transcriptional heterogeneity in aged human muscle stem cells

16 May 2023

Abstract excerpt

Age-related loss of muscle mass and function negatively impacts healthspan and lifespan. Satellite cells function as muscle stem cells in muscle maintenance and regeneration by self-renewal, activation, proliferation and differentiation. These processes are perturbed in aging at the stem cell population level, contributing to muscle loss. However, how representation of subpopulations within the human satellite...

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PMID: 37192223
DOI: 10.1371/journal.pone.0285018

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