Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Palmitate-Induced IRE1–XBP1–ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration

26 Oct 2020

Abstract excerpt

Abstract Elevated uptake of saturated fatty acid palmitate is associated with metastatic progression of cancer cells; however, the precise signaling mechanism behind the phenomenon is unclear. The loss of cell adhesion proteins, such as desmoplakin (DSP), is a key driving event in the transformation of cancer cells to more aggressive phenotypes. Here, we investigated the mechanism by which palmitate induces the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to DNA Repair Mechanisms
Share to Endoplasmic Reticulum Stress and Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33106375
DOI: 10.1158/1541-7786.mcr-19-0480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Palmitate-Induced IRE1–XBP1–ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell MigrationPMID 33106375Read ↗

ZEB1-regulated inflammatory phenotype in breast cancer cells.Semantic proximity Read ↗

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesisSemantic proximity Read ↗

S-Palmitoylation as a Functional Regulator of Proteins Associated with Cisplatin Resistance in Bladder CancerSemantic proximity Read ↗

ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathwaysSemantic proximity Read ↗

Insulin regulates lymphatic endothelial function via palmitoylationSemantic proximity Read ↗

Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum StressSemantic proximity Read ↗

Mixed lineage kinase ZAK promotes epithelial-mesenchymal transition in cancer progression.Semantic proximity Read ↗

Lipogenesis-driven EGFR palmitoylation enables metastatic immune evasion in triple-negative breast cancerSemantic proximity Read ↗

A topology-dependent IRE1α signaling axis generates a cryptic XBP1 isoform present in human cancersSemantic proximity Read ↗

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 ActivationSemantic proximity Read ↗

Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis.Semantic proximity Read ↗

Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.