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Article

Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis.

Open biology - 1 Oct 2021

Kadry Yasmin A, Lee Jia-Ying, Witze Eric S

Abstract excerpt

The epidermal growth factor receptor (EGFR) is an essential driver of oncogenic signalling, and EGFR inhibitors are some of the earliest examples of successful targeted therapies in multiple types of cancer. The tractability of EGFR as a therapeutic target is overshadowed by the inevitable drug resistance that develops. Overcoming resistance mechanisms requires a deeper understanding of EGFR regulation in cancer...

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Share to Acyltransferases
Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 34610265
DOI: 10.1098/rsob.210033
PMCID: PMC8492172

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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