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Article

ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways

8 Jun 2012

Abstract excerpt

BACKGROUND: Amplification of the 8p11-12 region has been found in approximately 15% of human breast cancer and is associated with poor prognosis. Previous genomic analysis has led us to identify the endoplasmic reticulum (ER) lipid raft-associated 2 (ERLIN2) gene as one of the candidate oncogenes within the 8p11-12 amplicon in human breast cancer, particularly in the luminal subtype. ERLIN2, an ER membrane...

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PMID: 22681620
DOI: 10.1186/1471-2407-12-225

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